Mucosal adjuvant activity of flagellin in aged mice
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چکیده
منابع مشابه
Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice
The recently discovered mammalian enzyme cyclic GMP-AMP synthase produces cyclic GMP-AMP (cGAMP) after being activated by pathogen-derived cytosolic double stranded DNA. The product can stimulate STING-dependent interferon type I signaling. Here, we explore the efficacy of cGAMP as a mucosal adjuvant in mice. We show that cGAMP can enhance the adaptive immune response to the model antigen ovalb...
متن کاملCorrection: Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice
[This corrects the article DOI: 10.1371/journal.pone.0110150.].
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Flagellin, the structural component of flagellar filament in various locomotive bacteria, is the ligand for Toll-like receptor 5 (TLR5) of host cells. TLR stimulation by various pathogen-associated molecular patterns leads to activation of innate and subsequent adaptive immune responses. Therefore, TLR ligands are considered attractive adjuvant candidates in vaccine development. In this study, ...
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The immunogenicity of bacterial flagellin has been reported in different studies. By its close interaction with the immune system, the flagellin represents an interesting adjuvant and vaccine candidate. Salmonella Typhimurium flagellin has already been tested as adjuvant to stimulate mucosal immunity. Here, we assessed the ability of Clostridium difficile flagellin FliC to act as a mucosal adju...
متن کاملMucosal and systemic adjuvant activity of alphavirus replicon particles.
Vaccination represents the most effective control measure in the fight against infectious diseases. Local mucosal immune responses are critical for protection from, and resolution of, infection by numerous mucosal pathogens. Antigen processing across mucosal surfaces is the natural route by which mucosal immunity is generated, as peripheral antigen delivery typically fails to induce mucosal imm...
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ژورنال
عنوان ژورنال: Mechanisms of Ageing and Development
سال: 2008
ISSN: 0047-6374
DOI: 10.1016/j.mad.2008.01.009